Differences between anti-myeloperoxidase- and anti-proteinase 3-associated renal disease
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منابع مشابه
Hydralazine Induces Myeloperoxidase and Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody Vasculitis and Leads to Pulmonary Renal Syndrome
We report a case of hydralazine-induced ANCA-associated glomerulonephritis with pulmonary hemorrhage. A 62-year-old Hispanic man with hypertension, who was being treated with hydralazine 100 mg three times a day for four and half years, presented to the hospital with severe anemia. He had acute kidney injury and urinalysis showed proteinuria, dysmorphic RBCs, and rare RBC cast. CT scan of the c...
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Anti-neutrophil cytoplasm antibodies (ANCA) are useful diagnostic markers in a range of small vessel vasculitides. While non-specific ANCA have been reported in association with a variety of autoimmune, haematological and infectious conditions, the combination of a cytoplasmic staining pattern on indirect immunofluorescence (IIF) of human neutrophils, with antibodies specific for proteinase 3 (...
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BACKGROUND AND OBJECTIVES This study evaluated predictors for patient and renal survival in patients with ANCA-associated vasculitis (AAV) with and without renal involvement. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS There were 273 consecutive AAV patients from January 1990 until December 2007 who were followed until death, loss to follow-up, or December 2010. Based on organ involvement, ...
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Recently it has been reported, that immunoglobulin Y (IgY) can be used instead of polyclonal antibodies extracted from mammals (IgG) for the purpose of diagnosis and therapy. These antibodies are found to have better properties in terms of specificity and ease of large-scale production. In addition, IgY binds neither to mammalian complement or Fc-receptors nor does it interfere with rheumatoid ...
متن کاملAnti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis.
Since the discovery of the link between anti-neutrophil cytoplasmic antibodies (ANCA) directed against proteinase-3 (PR3) and myeloperoxidase (MPO) and small-vessel vasculitis, the diagnostic potential of these antibodies has been appreciated [1,2]. High sensitivity and specificity of validated antigen-specific tests for Wegener’s granulomatosis (WG), microscopic polyangiitis (MPA) and the rena...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1995
ISSN: 0085-2538
DOI: 10.1038/ki.1995.23